Products / High-Resolution Episcopic Microscopy (HREM)
High-Resolution Episcopic Microscopy (HREM) 3D biomedical imaging systems for structural analysis of samples in 2D and 3D
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What is High-Resolution Episcopic Microscopy (HREM)?
High-Resolution Episcopic Microscopy (HREM) is a 3D imaging technique for visualising samples ranging from 1-30mm. Resin mounted samples are stained, then sectioned repeatedly with the remaining block face imaged, creating high-resolution 3D stacks at 1–8-micron voxel resolution.
Advantages of HREM
High-Resolution Episcopic Microscopy (HREM) is a 3D imaging technique of ex-vivo samples providing multiple benefits over conventional 3D techniques such as resolution, cost and more.
Produces 1-8 micron complete voxel resolution over an entire volumetric dataset
Image dense tissue and bone at high contrast without variation
No sample clearing, distortion or interpolation
Capable of imaging up to 25mm samples with micron resolution
Flexibility for a Range of Samples
High-Resolution Episcopic Microscopy (HREM) provides exceptional clarity and resolution, even when imaging denser tissues or tissues with varying opacities.
Unlike conventional techniques, eliminate the need for tissue clearing and interpolation, making the imaging process more efficient and convenient. HREM produces high-contrast results, enhancing the visualization of anatomical structures and details.
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Capable of visualising samples up to 30mm in one capture or greater with scanning
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Suitable for bone and denser tissue samples
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High contrast images even in higher density areas
Mouse Embryos
Drosophila
Fruit & Plant Samples
Barley
Zebrafish
Other Fish Samples
Embryonic Hearts
Reproductive Systems
Optical HREM Systems
We offer two main Optical HREM system solutions, available worldwide, offering flexibility in budget and in capture. Each systems can achieve highly detailed 3D image stacks, while allowing the systems to be accessible to more.
Tim Mohun
(DMDD)
'HREM data has allowed the DMDD team to identify nearly 400 different phenotypes in knockout mouse embryos. These range from large-scale organ malformations to the abnormal development of nerves and blood vessels.'
Dr Duncan Sparrow
(DEPARTMENT OF PHYSIOLOGY, ANATOMY & GENETICS, UNIVERSITY OF OXFORD)
'We are extremely happy with the high quality 3D imaging of our samples. The OHREM system is very flexible, and fully upgradable. We initially only had funds for the single-channel model. However, when we got another grant 12 months later, able to upgrade our system to a 2-channel model with less than 24 hours downtime. The system is very reliable, with virtually no maintenance required. For example, we have used our machine 24/7 for months on end, without any repairs required. In the 2 years we have had the OHREM, we have achieved completely consistent data quality. Aftersales service is friendly, prompt and informative. Chris is also committed to further developing the OHREM technology and engaging with users. For example, he attended a one day workshop organised at University College London in 2019, where users from around the worldwide were able to swap tips and tricks to improve HREM workflows. He made many valuable comments, and was also able to keep us updated on the latest technical developments for the OHREM system.'
Contact our High-Resolution Episcopic Microscopy (HREM) Experts
Want to know more about HREM, ask for a quote or get questions answered. Contact us and we can help answer all your questions.
Phone:
+44(0) 1462633500
Email:
hello@indigo-scientific.co.uk