Optical HREM (high resolution episcopic microscopy) imaging has been used for almost 15 years to produce scientific results for publication. The listing below provides a selection.

Research papers listing

  • Claire Walsh, Natalie Holroyd, Eoin Finnerty, Sean G. Ryan, Paul W. Sweeney, Rebecca J. Shipley, Simon Walker-Samuel
    Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs.
    bioRxiv, 2020 https://doi.org/10.1101/2020.04.03.023978
  • Pokhrel, N., E. Ben-Tal Cohen, O. Genin, D. Sela-Donenfeld and Y. Cinnamon
    Cellular and morphological characterization of blastoderms from freshly laid broiler eggs.
    Poult Sci, 2017 PubMed abstract
  • Zhou, Z., J. Wang, C. Guo, W. Chang, J. Zhuang, P. Zhu, and X. Li
    Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart
    Development and Disease Cell Rep, 2017. 18(4), 1019-1032 PubMed abstract
  • Le Garrec, J.F., J.N. Dominguez, A. Desgrange, K.D. Ivanovitch, E. Raphael, J.A. Bangham, M. Torres, E. Coen, T.J. Mohun, and S.M. Meilhac
    A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics.
    Elife, 2017. 6 PubMed abstract
  • Geyer, S.H., L.F. Reissig, M. Husemann, C. Hofle, R. Wilson, F. Prin, D. Szumska, A. Galli, D.J. Adams, J. White, T.J. Mohun, and W.J. Weninger
    Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21-S23.
    J Anat, 2017. 231(4): 600-614 PubMed abstract
  • Geyer, S.H., L. Reissig, J. Rose, R. Wilson, F. Prin, D. Szumska, R. Ramirez-Solis, C. Tudor, J. White, T.J. Mohun, and W.J. Weninger
    A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5). J Anat, 2017. 230(5): 710-719 PubMed abstract
  • Geyer, S.H., B. Maurer-Gesek, L.F. Reissig and W.J. Weninger
    High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials.
    J Vis Exp, 2017(125) PubMed abstract
  • Anderson, R.H., B. Jensen, T.J. Mohun, S.E. Petersen, N. Aung, F. Zemrak, R.N. Planken, and D.H. MacIver
    Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes?
    Can J Cardiol, 2017. 33(6): p. 747-757 PubMed abstract
  • Aiello, V.D., D.E. Spicer, R.H. Anderson, N.A. Brown and T.J. Mohun
    The independence of the infundibular building blocks in the setting of double-outlet right ventricle.
    Cardiol Young, 2017. 27(5): p. 825-836 PubMed abstract
  • Zak, J., V. Vives, D. Szumska, A. Vernet, J.E. Schneider, P. Miller, E.A. Slee, S. Joss, Y. Lacassie, E. Chen, L.F. Escobar, M. Tucker, A.S. Aylsworth, H.A. Dubbs, A.T. Collins, J. Andrieux, A. Dieux-Coeslier, E. Haberlandt, D. Kotzot, D.A. Scott, M.J. Parker, Z. Zakaria, Y.S. Choy, D. Wieczorek, A.M. Innes, K.R. Jun, S. Zinner, F. Prin, C.A. Lygate, P. Pretorius, J.A. Rosenfeld, T.J. Mohun, and X. Lu
    = ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.
    Cell Death Differ, 2016. 23(12): p. 1973-1984 PubMed abstract
  • Wilson, R., S.H. Geyer, L. Reissig, J. Rose, D. Szumska, E. Hardman, F. Prin, C. McGuire, R. Ramirez-Solis, J. White, A. Galli, C. Tudor, E. Tuck, C. Mazzeo, J.C. Smith, E. Robertson, D.J. Adams, T. Mohun, and W.J. Weninger
    Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wellcome Open Res, 2016. 1: p. 1 PubMed abstract
  • Lana-Elola, E., S. Watson-Scales, A. Slender, D. Gibbins, A. Martineau, C. Douglas, T. Mohun, E.M. Fisher, and V. Tybulewicz
    Genetic dissection of Down syndrome- associated congenital heart defects using a new mouse mapping panel.
    Elife, 2016. 5. PubMed abstract
  • Huang, Y.C., F. Chen and X. Li
    Clarification of mammalian cloacal morphogenesis using high-resolution episcopic microscopy.
    Dev Biol, 2016. 409(1): p. 106-13. PubMed abstract
  • Henkelman, R.M., M. Friedel, J.P. Lerch, R. Wilson and T. Mohun
    Comparing homologous microscopic sections from multiple embryos using HREM.
    Dev Biol, 2016. 415(1): p. 1-5. PubMed abstract
  • Dickinson, M.E., A.M. Flenniken, X. Ji, L. Teboul, M.D. Wong, J.K. White, T.F. Meehan, W.J. Weninger, H. Westerberg, H. Adissu, C.N. Baker, L. Bower, J.M. Brown, L.B. Caddle, F. Chiani, D. Clary, J. Cleak, M.J. Daly, J.M. Denegre, B. Doe, M.E. Dolan, S.M. Edie, H. Fuchs, V. Gailus-Durner, A. Galli, A. Gambadoro, J. Gallegos, S. Guo, N.R. Horner, C.W. Hsu, S.J. Johnson, S. Kalaga, L.C. Keith, L. Lanoue, T.N. Lawson, M. Lek, M. Mark, S. Marschall, J. Mason, M.L. McElwee, S. Newbigging, L.M. Nutter, K.A. Peterson, R. Ramirez-Solis, D.J. Rowland, E. Ryder, K.E. Samocha, J.R. Seavitt, M. Selloum, Z. Szoke-Kovacs, M. Tamura, A.G. Trainor, I. Tudose, S. Wakana, J. Warren, O. Wendling, D.B. West, L. Wong, A. Yoshiki, C. International Mouse Phenotyping, L. Jackson, I.C.d.l.S. Infrastructure Nationale Phenomin, L. Charles River, M.R.C. Harwell, P. Toronto Centre for, I. Wellcome Trust Sanger, R.B. Center, D.G. MacArthur, G.P. Tocchini-Valentini, X. Gao, P. Flicek, A. Bradley, W.C. Skarnes, M.J. Justice, H.E. Parkinson, M. Moore, S. Wells, R.E. Braun, K.L. Svenson, M.H. de Angelis, Y. Herault, T. Mohun, A.M. Mallon, R.M. Henkelman, S.D. Brown, D.J. Adams, K.C. Lloyd, C. McKerlie, A.L. Beaudet, M. Bucan, and S.A. Murray
    High-throughput discovery of novel developmental phenotypes.
    Nature, 2016. 537(7621): p. 508-514. PubMed abstract
  • Captur, G., R. Wilson, M.F. Bennett, G. Luxan, A. Nasis, J.L. de la Pompa, J.C. Moon, and T.J. Mohun
    Morphogenesis of myocardial trabeculae in the mouse embryo.
    J Anat, 2016. 229(2): p. 314-25. PubMed abstract
  • Anderson, R.H., S. Mori, D.E. Spicer, N.A. Brown and T.J. Mohun
    Development and Morphology of the Ventricular Outflow Tracts.
    World J Pediatr Congenit Heart Surg, 2016. 7(5): p. 561-77. PubMed abstract
  • Anderson, R.H., N.A. Brown and T.J. Mohun
    Insights regarding the normal and abnormal formation of the atrial and ventricular septal structures.
    Clin Anat, 2016. 29(3): p. 290-304. PubMed abstract
  • Spicer, D.E., D.J. Henderson, B. Chaudhry, T.J. Mohun and R.H. Anderson
    The anatomy and development of normal and abnormal coronary arteries.
    Cardiol Young, 2015. 25(8): p. 1493-503. PubMed abstract
  • Notari, M., Y. Hu, G. Sutendra, Z. Dedeic, M. Lu, L. Dupays, A. Yavari, C.A. Carr, S. Zhong, A. Opel, A. Tinker, K. Clarke, H. Watkins, D.J. Ferguson, D.P. Kelsell, S. de Noronha, M.N. Sheppard, M. Hollinshead, T.J. Mohun, and X. Lu
    iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
    Proc Natl Acad Sci USA, 2015. 112(9): p. E973-81. PubMed abstract
  • Matsui, H., S.Y. Ho, T.J. Mohun and H.M. Gardiner
    Postmortem high-resolution episcopic microscopy (HREM) of small human fetal hearts.
    Ultrasound Obstet Gynecol, 2015. 45(4): p. 492-3. PubMed abstract
  • Geyer, S.H., I.E. Tinhofer, D.B. Lumenta, L.P. Kamolz, L. Branski, C.C. Finnerty, D.N. Herndon, and W.J. Weninger
    High-resolution episcopic microscopy (HREM): a useful technique for research in wound care.
    Ann Anat, 2015. 197: p. 3-10. PubMed abstract
  • Dupays, L., C. Shang, R. Wilson, S. Kotecha, S. Wood, N. Towers, and T. Mohun
    Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis.
    Cell Rep, 2015. 13(1): p. 183-195. PubMed abstract
  • Bharucha, T., D.E. Spicer, T.J. Mohun, D. Black, G.W. Henry, and R.H. Anderson
    Cor triatriatum or divided atriums: which approach provides the better understanding?
    Cardiol Young, 2015. 25(2): p. 193-207. PubMed abstract
  • Bailliard, F., D.E. Spicer, T.J. Mohun, G.W. Henry and R.H. Anderson
    The problems that exist when considering the anatomic variability between the channels that permit interventricular shunting.
    Cardiol Young, 2015. 25(1): p. 15-28. PubMed abstract
  • Anderson, R.H., D.E. Spicer, G.W. Henry, C. Rigsby, A.M. Hlavacek, and T.J. Mohun
    What is aortic overriding?
    Cardiol Young, 2015. 25(4): p. 612-25. PubMed abstract
  • Anderson, R.H., T.J. Mohun and N.A. Brown
    Clarifying the morphology of the ostium primum defect.
    J Anat, 2015. 226(3): p. 244-57. PubMed abstract
  • Weninger, W.J., S.H. Geyer, A. Martineau, A. Galli, D.J. Adams, R. Wilson, and T.J. Mohun, Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.
    Dis Model Mech, 2014. 7(10): p. 1143-52. PubMed abstract
  • Spicer, D.E., J.M. Bridgeman, N.A. Brown, T.J. Mohun and R.H. Anderson, The anatomy and development of the cardiac valves.
    Cardiol Young, 2014. 24(6): p. 1008-22. PubMed abstract
  • Rochais, F., R. Sturny, C.M. Chao, K. Mesbah, M. Bennett, T.J. Mohun, S. Bellusci, and R.G. Kelly, FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry.
    Cardiovasc Res, 2014. 104(3): p. 432-42. PubMed abstract
  • Rana, M.S., M. Theveniau-Ruissy, C. De Bono, K. Mesbah, A. Francou, M. Rammah, J.N. Dominguez, M. Roux, B. Laforest, R.H. Anderson, T. Mohun, S. Zaffran, V.M. Christoffels, and R.G. Kelly
    Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.
    Circ Res, 2014. 115(9): p. 790-9. PubMed abstract
  • Geyer, S.H., M.M. Nohammer, M. Matha, L. Reissig, I.E. Tinhofer, and W.J. Weninger
    High-resolution episcopic microscopy (HREM): a tool for visualizing skin biopsies.
    Microsc Microanal, 2014. 20(5): p. 1356-64. PubMed abstract
  • Captur, G., L.R. Lopes, V. Patel, C. Li, P. Bassett, P. Syrris, D.M. Sado, V. Maestrini, T.J. Mohun, W.J. McKenna, V. Muthurangu, P.M. Elliott, and J.C. Moon
    Abnormal cardiac formation in hypertrophic cardiomyopathy: fractal analysis of trabeculae and preclinical gene expression.
    Circ Cardiovasc Genet, 2014. 7(3): p. 241-8. PubMed abstract
  • Anderson, R.H., D.E. Spicer, N.A. Brown and T.J. Mohun
    The development of septation in the four-chambered heart.
    Anat Rec (Hoboken), 2014. 297(8): p. 1414-29. PubMed abstract
  • Vettukattil, J.J., Z. Ahmed, A.P. Salmon, T. Mohun and R.H. Anderson
    Defects in the oval fossa: morphologic variations and impact on transcatheter closure.
    J Am Soc Echocardiogr, 2013. 26(2): p. 192-9. PubMed abstract
  • Norris, F.C., M.D. Wong, N.D. Greene, P.J. Scambler, T. Weaver, W.J. Weninger, T.J. Mohun, R.M. Henkelman, and M.F. Lythgoe
    A coming of age: advanced imaging technologies for characterising the developing mouse.
    Trends Genet, 2013. 29(12): p. 700-11. PubMed abstract
  • Maurer, B., S.H. Geyer and W.J. Weninger
    A chick embryo with a yet unclassified type of cephalothoracopagus malformation and a hypothesis for explaining its genesis.
    Anat Histol Embryol, 2013. 42(3): p. 191-200. PubMed abstract
  • Captur, G., V. Muthurangu, C. Cook, A.S. Flett, R. Wilson, A. Barison, D.M. Sado, S. Anderson, W.J. McKenna, T.J. Mohun, P.M. Elliott, and J.C. Moon
    Quantification of left ventricular trabeculae using fractal analysis.
    J Cardiovasc Magn Reson, 2013. 15: p. PubMed abstract
  • Breckenridge, R.A., I. Piotrowska, K.E. Ng, T.J. Ragan, J.A. West, S. Kotecha, N. Towers, M. Bennett, P.C. Kienesberger, R.T. Smolenski, H.K. Siddall, J.L. Offer, M.M. Mocanu, D.M. Yelon, J.R. Dyck, J.L. Griffin, A.Y. Abramov, A.P. Gould, and T.J. Mohun
    Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.
    PLoS Biol, 2013. 11(9): p. e1001666. PubMed abstract
  • Bamforth, S.D., B. Chaudhry, M. Bennett, R. Wilson, T.J. Mohun, L.H. Van Mierop, D.J. Henderson, and R.H. Anderson
    Clarification of the identity of the mammalian fifth pharyngeal arch artery.
    Clin Anat, 2013. 26(2): p. 173-82. PubMed abstract
  • Anderson, R.H., D.E. Spicer, J.M. Giroud and T.J. Mohun
    Tetralogy of Fallot: nosological, morphological, and morphogenetic considerations.
    Cardiol Young, 2013. 23(6): p. 858-66. PubMed abstract
  • Anderson, R.H., N.A. Brown, T.J. Mohun and A.F. Moorman
    Insights from cardiac development relevant to congenital defects and adult clinical anatomy.
    J Cardiovasc Transl Res, 2013. 6(2): p. 107-17. PubMed abstract
  • Sizarov, A., W.H. Lamers, T.J. Mohun, N.A. Brown, R.H. Anderson, and A.F. Moorman
    Three-dimensional and molecular analysis of the arterial pole of the developing human heart.
    J Anat, 2012. 220(4): p. 336-49. PubMed abstract
  • Mohun, T.J. and W.J. Weninger
    Episcopic three-dimensional imaging of embryos.
    Cold Spring Harb Protoc, 2012. 2012(6): p. 641-6. PubMed abstract
  • Mohun, T.J. and W.J. Weninger
    Embedding embryos for episcopic fluorescence image capturing (EFIC).
    Cold Spring Harb Protoc, 2012. 2012(6): p. 675-7. PubMed abstract
  • Mohun, T.J. and W.J. Weninger
    Embedding embryos for high-resolution episcopic microscopy (HREM).
    Cold Spring Harb Protoc, 2012. 2012(6): p. 678-80. PubMed abstract
  • Mohun, T.J. and W.J. Weninger
    Generation of volume data by episcopic three- dimensional imaging of embryos.
    Cold Spring Harb Protoc, 2012. 2012(6): p. 681-2. PubMed abstract
  • Lescroart, F., T. Mohun, S.M. Meilhac, M. Bennett and M. Buckingham
    Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing.
    Circ Res, 2012. 111(10): p. 1313-22. PubMed abstract
  • Gindes, L., H. Matsui, R. Achiron, T. Mohun, S.Y. Ho, and H. Gardiner,
    Comparison of ex-vivo high-resolution episcopic microscopy with in-vivo four-dimensional high- resolution transvaginal sonography of the first-trimester fetal heart.
    Ultrasound Obstet Gynecol, 2012. 39(2): p. 196-202. PubMed abstract
  • Anderson, R.H., B. Chaudhry, T.J. Mohun, S.D. Bamforth, D. Hoyland, H.M. Phillips, S. Webb, A.F. Moorman, N.A. Brown, and D.J. Henderson
    Normal and abnormal development of the intrapericardial arterial trunks in humans and mice.
    Cardiovasc Res, 2012. 95(1): p. 108-15. PubMed abstract
  • Mohun, T.J. and W.J. Weninger
    Imaging heart development using high-resolution episcopic microscopy.
    Curr Opin Genet Dev, 2011. 21(5): p. 573-8. PubMed abstract
  • de Boer, B.A., A.T. Soufan, J. Hagoort, T.J. Mohun, M.J. van den Hoff, A. Hasman, F.P. Voorbraak, A.F. Moorman, and J.M. Ruijter
    The interactive presentation of 3D information obtained from reconstructed datasets and 3D placement of single histological sections with the 3D portable document format.
    Development, 2011. 138(1): p. 159-67. PubMed abstract
  • Anderson, R.H., T.J. Mohun and A.F. Moorman
    What is a ventricle?
    Cardiol Young, 2011. 21 Suppl 2: p. 14-22. PubMed abstract
  • Matsui, H., T. Mohun and H.M. Gardiner
    Three-dimensional reconstruction imaging of the human foetal heart in the first trimester.
    Eur Heart J, 2010. 31(4): p. 415. PubMed abstract
  • Dunlevy, L., M. Bennett, A. Slender, E. Lana-Elola, V.L. Tybulewicz, E.M. Fisher, and T. Mohun
    Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
    Cardiovasc Res, 2010. 88(2): p. 287-95. PubMed abstract
  • Anderson, R.H., A. Cook, N.A. Brown, D.J. Henderson, B. Chaudhry, and T. Mohun
    Development of the outflow tracts with reference to aortopulmonary windows and aortoventricular tunnels.
    Cardiol Young, 2010. 20 Suppl 3: p. 92-9. PubMed abstract
  • Geyer, S.H., T.J. Mohun and W.J. Weninger
    Visualizing vertebrate embryos with episcopic 3D imaging techniques.
    Scientific World Journal, 2009. 9: p. 1423-37. PubMed abstract
  • Weninger, W.J. and T.J. Mohun
    Three-dimensional analysis of molecular signals with episcopic imaging techniques.
    Methods Mol Biol, 2007. 411: p. 35-46. PubMed abstract
  • Weninger, W.J., S.H. Geyer, T.J. Mohun, D. Rasskin-Gutman, T. Matsui, I. Ribeiro, F. Costa Lda, J.C. Izpisua-Belmonte, and G.B. Muller
    High-resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology.
    Anat Embryol (Berl), 2006. 211(3): p. 213-21. PubMed abstract
  • Going, J.J. and T.J. Mohun
    Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer.
    Breast Cancer Res Treat, 2006. 97(3): p. 285-91. PubMed abstract

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